Abstract
We report that maintaining rats under chloral hydrate anesthesia for the first 3 h following the administration of 3,4-methylenedioxymethamphetamine (MDMA) blocks the decrease in forebrain concentrations of 5-hydroxytryptamine (5-HT) measured 1 week later. In contrast, the acute effect of MDMA (3 h) on forebrain 5-HT was not altered by the anesthetic. This protective effect of chloral hydrate was not due to an anesthetic-induced hypothermia but may be related to the hypothesized role of dopamine in the neurotoxic effects of MDMA.
MeSH terms
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3,4-Methylenedioxyamphetamine / analogs & derivatives*
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3,4-Methylenedioxyamphetamine / antagonists & inhibitors
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3,4-Methylenedioxyamphetamine / toxicity
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Anesthesia*
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Animals
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Cerebral Cortex / cytology
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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Chloral Hydrate / pharmacology*
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Hippocampus / cytology
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Male
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N-Methyl-3,4-methylenedioxyamphetamine
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Premedication
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism*
Substances
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Serotonin
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Chloral Hydrate
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3,4-Methylenedioxyamphetamine
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N-Methyl-3,4-methylenedioxyamphetamine