Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties

Vigilio Ballabeni; Massimiliano Tognolini; Carmine Giorgio; Simona Bertoni; Renato Bruni; Elisabetta Barocelli

doi:10.1016/j.fitote.2009.10.002

Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties

Fitoterapia. 2010 Jun;81(4):289-95. doi: 10.1016/j.fitote.2009.10.002. Epub 2009 Oct 13.

Authors

Vigilio Ballabeni¹, Massimiliano Tognolini, Carmine Giorgio, Simona Bertoni, Renato Bruni, Elisabetta Barocelli

Affiliation

¹ Department of Pharmacological, Biological and Chemical Applied Sciences, University of Parma, Via GP Usberti 27/a, 43100 Parma, Italy.

PMID: 19825398
DOI: 10.1016/j.fitote.2009.10.002

Abstract

Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30-100mg/kg os) and trans-cinnamaldehyde (10mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrolein / analogs & derivatives*
Acrolein / isolation & purification
Acrolein / pharmacology
Acrolein / therapeutic use
Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Carrageenan
Cell Line, Tumor
Cinnamates
Edema / chemically induced
Edema / drug therapy*
Gastric Mucosa / drug effects
Humans
Inflammation Mediators / metabolism*
Lipopolysaccharides
Macrophages / drug effects
Male
Neuroblastoma / drug therapy
Ocotea / chemistry*
Oils, Volatile / chemistry
Oils, Volatile / pharmacology
Oils, Volatile / therapeutic use*
Phytotherapy
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Rats
Rats, Wistar

Substances

Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Cinnamates
Inflammation Mediators
Lipopolysaccharides
Oils, Volatile
Plant Extracts
methyl cinnamate
Acrolein
Carrageenan
cinnamaldehyde