Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

W Mei Kok; Denis B Scanlon; John A Karas; Luke A Miles; Deborah J Tew; Michael W Parker; Kevin J Barnham; Craig A Hutton

doi:10.1039/b912784d

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

Chem Commun (Camb). 2009 Nov 7:(41):6228-30. doi: 10.1039/b912784d. Epub 2009 Sep 1.

Authors

W Mei Kok¹, Denis B Scanlon, John A Karas, Luke A Miles, Deborah J Tew, Michael W Parker, Kevin J Barnham, Craig A Hutton

Affiliation

¹ School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia.

PMID: 19826677
DOI: 10.1039/b912784d

Abstract

Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Amyloid beta-Peptides / chemical synthesis*
Amyloid beta-Peptides / chemistry
Cross-Linking Reagents
Molecular Sequence Data
Protein Multimerization

Substances

Amyloid beta-Peptides
Cross-Linking Reagents