The effects of anthropometry and pre-race experience on race performance were investigated in male nonprofessional ultra-runners performing a multistage run of 1,200 km over 17 days. Of 24 athletes examined pre-race, 14 (58%) dropped out during the race due to overuse injuries of the lower limbs. During the race, body mass, thickness of the calf skin-fold, skeletal muscle mass, and percent body fat decreased significantly, while circumference of the upper arm, thickness of triceps, and abdominal skin-fold as well as Body Mass Index decreased significantly in the finishers. Neither anthropometry nor pre-race experience and training volume nor previously finished races were associated with the race time of the finishers. In future studies of ultra-runners, the influence of psychological (cognitive and emotional) predictors on race outcome should be investigated.