Abstract
Chemotherapy-induced emesis is the most severe side effect in term of patient's perception. Current anti-emetic regimen as high dose metoclopramide can achieve a complete response in less than 60% of patients. The HT3 receptors appear to be the principal mediator of the emetic effect and their blockade have a clear activity in the prevention of acute drug-induced emesis, superior to reference regimens.
MeSH terms
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Antiemetics / classification
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Antiemetics / pharmacology
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Antiemetics / therapeutic use*
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Antineoplastic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Dexamethasone / therapeutic use
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Dopamine Antagonists
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Drug Evaluation
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Drug Therapy, Combination
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Humans
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Metoclopramide / pharmacology
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Metoclopramide / therapeutic use
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Receptors, Serotonin / classification
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology*
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Serotonin Antagonists / pharmacology*
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Serotonin Antagonists / therapeutic use
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Vomiting / chemically induced*
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Vomiting / drug therapy
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Vomiting / physiopathology
Substances
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Antiemetics
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Antineoplastic Agents
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Antipsychotic Agents
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Dopamine Antagonists
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Receptors, Serotonin
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Serotonin Antagonists
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Dexamethasone
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Metoclopramide