Is antigen specificity of autoreactive T cells the key to islet entry?

Cristina Penaranda; Jeffrey A Bluestone

doi:10.1016/j.immuni.2009.09.006

Is antigen specificity of autoreactive T cells the key to islet entry?

Immunity. 2009 Oct 16;31(4):534-6. doi: 10.1016/j.immuni.2009.09.006.

Authors

Cristina Penaranda¹, Jeffrey A Bluestone

Affiliation

¹ Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.

PMID: 19833083
DOI: 10.1016/j.immuni.2009.09.006

Abstract

It has been widely hypothesized that pancreatic islet infiltrates include both islet-antigen-specific and nonspecific T cells. In this issue of Immunity, Lennon et al. (2009) demonstrate that islet-antigen specificity is required for accumulation in the islets.

Publication types

Comment

MeSH terms

Animals
Autoantigens / immunology
Autoimmunity / immunology*
Diabetes Mellitus, Type 1 / immunology*
Islets of Langerhans / immunology*
Islets of Langerhans / metabolism
Mice
Mice, Inbred NOD
Mice, Transgenic
Receptors, Antigen, T-Cell / immunology*
Receptors, Antigen, T-Cell / metabolism
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / metabolism
T-Lymphocyte Subsets / transplantation

Substances

Autoantigens
Receptors, Antigen, T-Cell