The relationship between body weight and depression among adolescent females has been the subject of considerable attention from researchers. The risk of experiencing this distress, however, is not equally distributed across members of all racial groups. African American girls are generally more satisfied with their bodies and thus may be less vulnerable to experiencing depression as a result of weight concerns. Several scholars have suggested that membership in African American culture provides social resources that protect black females from experiencing high levels of weight-based psychological distress. We examine the relationship between body size and depression and the potentially moderating role of African American cultural experiences using data from the Family and Community Health Study (FACHS). Assessing a cohort of 342 African American girls ages 12-14, we found support for a link between weight and depression. There was no evidence, however, that exposure to African American culture moderated this relationship.