Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11

Angew Chem Int Ed Engl. 2009;48(47):8952-7. doi: 10.1002/anie.200904778.
No abstract available

MeSH terms

  • Animals
  • Binding Sites
  • Cell Line
  • Computer Simulation
  • Crystallography, X-Ray
  • Cyclin-Dependent Kinase 8 / chemistry*
  • Cyclin-Dependent Kinase 8 / metabolism
  • Cyclin-Dependent Kinases / chemistry*
  • Cyclin-Dependent Kinases / metabolism
  • High-Throughput Screening Assays
  • Humans
  • Isoquinolines / chemistry*
  • Ligands*
  • Polycyclic Compounds / chemistry*
  • Porifera / chemistry
  • Protein Structure, Tertiary
  • rho-Associated Kinases / chemistry*
  • rho-Associated Kinases / metabolism

Substances

  • Isoquinolines
  • Ligands
  • Polycyclic Compounds
  • cortistatin A
  • rho-Associated Kinases
  • CDK11a protein, human
  • Cyclin-Dependent Kinase 8
  • Cyclin-Dependent Kinases