Abstract
In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated Chinese hamster ovary (CHO) cells was examined. The bystander effect was studied through medium transfer experiments. Cytokinesis-block micronucleus (CBMN) assay was performed to quantify the chromosome damage induced by alpha-particle irradiation. Our results showed that the alpha-particle induced micronuclei (MN) frequencies were suppressed with the presence of Magnolol.
Copyright 2009 Elsevier Ltd. All rights reserved.
MeSH terms
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Alpha Particles
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Animals
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Biphenyl Compounds / administration & dosage*
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Bystander Effect / drug effects*
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Bystander Effect / radiation effects
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CHO Cells
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Chromosome Aberrations / drug effects*
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Chromosome Aberrations / radiation effects*
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Cricetinae
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Cricetulus
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Dose-Response Relationship, Drug
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Dose-Response Relationship, Radiation
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Lignans / administration & dosage*
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Radiation Tolerance / drug effects*
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Radiation-Protective Agents / administration & dosage
Substances
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Biphenyl Compounds
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Lignans
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Radiation-Protective Agents
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magnolol