Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection--a possible relationship

Leuk Lymphoma. 2009 Oct;50(10):1661-5. doi: 10.1080/10428190903162743.

Abstract

Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vírus- 8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / virology
  • Bone Marrow / pathology
  • Bone Marrow / virology
  • Castleman Disease / blood
  • Castleman Disease / drug therapy
  • Castleman Disease / etiology*
  • Castleman Disease / pathology
  • Castleman Disease / virology
  • DNA, Viral / blood
  • Female
  • Herpesvirus 6, Human / isolation & purification*
  • Humans
  • Lymph Nodes / pathology
  • Lymph Nodes / virology
  • Methotrexate / therapeutic use
  • POEMS Syndrome / drug therapy
  • POEMS Syndrome / etiology*
  • POEMS Syndrome / virology
  • Paraproteins / analysis
  • Prednisone / therapeutic use
  • Roseolovirus Infections / complications*
  • Thyroiditis, Autoimmune / complications
  • Vitamin B Complex / therapeutic use

Substances

  • DNA, Viral
  • Paraproteins
  • Vitamin B Complex
  • Prednisone
  • Methotrexate