Abstract
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Annonaceae / chemistry*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Aporphines / isolation & purification
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Aspergillus niger / drug effects
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Humans
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Indonesia
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Mycobacterium / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Polyynes / chemistry
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Polyynes / isolation & purification*
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Polyynes / pharmacology
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Saccharomyces cerevisiae / drug effects
Substances
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Aporphines
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Diterpenes
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Polyynes
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liriodenine