Abstract
Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen. Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.
MeSH terms
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Adolescent
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Adult
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Analysis of Variance
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Anticonvulsants / therapeutic use*
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Carbamazepine / blood
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Carbamazepine / therapeutic use
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Child
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Child, Preschool
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Drug Therapy, Combination
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Epilepsy / blood
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Epilepsy / drug therapy*
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Female
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Humans
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Infant
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Male
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Phenytoin / blood
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Phenytoin / therapeutic use
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Succinimides / blood
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Succinimides / therapeutic use*
Substances
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Anticonvulsants
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Succinimides
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methsuximide
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N-desmethylmethsuximide
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Carbamazepine
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Phenytoin