Projection from visual areas V2 and prostriata to caudal auditory cortex in the monkey

Cereb Cortex. 2010 Jul;20(7):1529-38. doi: 10.1093/cercor/bhp213. Epub 2009 Oct 29.

Abstract

Studies in humans and monkeys report widespread multisensory interactions at or near primary visual and auditory areas of neocortex. The range and scale of these effects has prompted increased interest in interconnectivity between the putatively "unisensory" cortices at lower hierarchical levels. Recent anatomical tract-tracing studies have revealed direct projections from auditory cortex to primary visual area (V1) and secondary visual area (V2) that could serve as a substrate for auditory influences over low-level visual processing. To better understand the significance of these connections, we looked for reciprocal projections from visual cortex to caudal auditory cortical areas in macaque monkeys. We found direct projections from area prostriata and the peripheral visual representations of area V2. Projections were more abundant after injections of temporoparietal area and caudal parabelt than after injections of caudal medial belt and the contiguous areas near the fundus of the lateral sulcus. Only one injection was confined to primary auditory cortex (area A1) and did not demonstrate visual connections. The projections from visual areas originated mainly from infragranular layers, suggestive of a "feedback"-type projection. The selective localization of these connections to peripheral visual areas and caudal auditory cortex suggests that they are involved in spatial localization.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amidines
  • Animals
  • Auditory Cortex / anatomy & histology*
  • Cholera Toxin / metabolism
  • Fluorescent Dyes
  • Macaca mulatta
  • Nerve Net / anatomy & histology*
  • Neural Pathways / anatomy & histology
  • Visual Cortex / anatomy & histology*

Substances

  • Amidines
  • Fluorescent Dyes
  • diamidino compound 253-50
  • Cholera Toxin