Renal hilus paraganglioma: a case report and brief review

Pathologica. 2009 Apr;101(2):89-92.

Abstract

Paraganglioma is a rare tumour that originates from any paraganglia. Among extra-adrenal paraganglioma, renal hilus is a rare location. The authors report a case of a 43-year-old female who was admitted for evaluation of a renal mass detected incidentally by ultrasound imaging. Suspecting malignancy, the patient underwent radical nephrectomy. Upon macroscopic examination, the lesion was located into the renal hilus. Histological study revealed a neoplasm constituted of nests of monomorphic cuboidal cells with basophilic granular cytoplasm and round to oval nuclei. Necrosis was absent. The proliferative index (Mib-1) was very low (< 5%). Immunohistochemical examination revealed reactivity for neuron specific enolase (NSE), chromogranin A and synaptophysin. The final diagnosis was renal hilus paraganglioma. The paper shows the difficulty in diagnostic approaches to paraganglioma in this atypical site.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Transitional Cell / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Nephrectomy
  • Paraganglioma, Extra-Adrenal / metabolism
  • Paraganglioma, Extra-Adrenal / pathology*
  • Paraganglioma, Extra-Adrenal / surgery
  • Pelvic Neoplasms / pathology