Resonance assignments for stromelysin complexed with a beta-sulfonyl hydroxamate inhibitor

Biomol NMR Assign. 2009 Dec;3(2):183-6. doi: 10.1007/s12104-009-9170-8. Epub 2009 Jun 19.

Abstract

The sequence specific (1)H, (13)C, and (15)N resonance assignments for stromelysin, a Matrix metalloproteinase, are reported in this article. Almost 70% of assignable backbone and side-chain atoms were assigned in this highly dynamic protein.

MeSH terms

  • Enzyme Inhibitors / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Hydroxamic Acids / metabolism*
  • Hydroxamic Acids / pharmacology
  • Matrix Metalloproteinase 3 / chemistry*
  • Matrix Metalloproteinase 3 / metabolism*
  • Matrix Metalloproteinase Inhibitors
  • Nuclear Magnetic Resonance, Biomolecular
  • Software
  • Sulfones / metabolism*
  • Sulfones / pharmacology

Substances

  • Enzyme Inhibitors
  • Hydroxamic Acids
  • Matrix Metalloproteinase Inhibitors
  • N-hydroxy-3-((4-methoxyphenyl)sulfonyl)-2-(((4-methoxyphenyl)sulfonyl)methyl)propanamide
  • Sulfones
  • Matrix Metalloproteinase 3