Abstract
Receptor-induced Ca(2+) oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca(2+) levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca(2+) entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.
MeSH terms
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Calcium Channels / physiology
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Calcium Signaling*
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Cell Adhesion Molecules / metabolism
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Cell Adhesion Molecules / physiology*
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Cell Line
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Cell Membrane / metabolism
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Endoplasmic Reticulum / metabolism
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Gene Expression Regulation
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Humans
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Membrane Proteins / metabolism
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Membrane Proteins / physiology*
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Neoplasm Proteins / metabolism
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Neoplasm Proteins / physiology*
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Stromal Interaction Molecule 1
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Stromal Interaction Molecule 2
Substances
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Calcium Channels
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Cell Adhesion Molecules
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Membrane Proteins
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Neoplasm Proteins
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STIM1 protein, human
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STIM2 protein, human
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Stromal Interaction Molecule 1
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Stromal Interaction Molecule 2