Asymmetric construction of rings A-D of daphnicyclidin-type alkaloids

Org Lett. 2009 Dec 17;11(24):5658-61. doi: 10.1021/ol902373m.

Abstract

The aza-Cope-Mannich reaction and ring-closing metathesis are key steps in the assembly of intermediates containing rings A-D of Daphniphyllum alkaloids of the daphnicyclidin type such as daphnipaxinin and oldhamine A.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkaloids
  • daphnipaxinin