Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia

V V Moroz; A B Salmina; A A Fursov; S V Mikhutkina; K Y Linev; N S Mantorova; S V Shakhmaeva

doi:10.1007/s10517-009-0580-5

Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia

Bull Exp Biol Med. 2009 May;147(5):570-2. doi: 10.1007/s10517-009-0580-5.

[Article in English, Russian]

Authors

V V Moroz¹, A B Salmina, A A Fursov, S V Mikhutkina, K Y Linev, N S Mantorova, S V Shakhmaeva

Affiliation

¹ Institute of General Resuscitation, Russian Academy of Medical Sciences, Moscow, Russia.

PMID: 19907741
DOI: 10.1007/s10517-009-0580-5

Abstract

The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD(+) metabolism and changes in activity of NAD(+)-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients after surgery for coronary heart disease with extracorporeal circulation. These changes in patients during the early postoperative period correlated with variations in CD38 expression on neuronal cells from postischemic rats with cognitive dysfunction.

MeSH terms

ADP-ribosyl Cyclase / metabolism
ADP-ribosyl Cyclase / physiology*
ADP-ribosyl Cyclase 1 / metabolism
Animals
Brain / cytology
Coronary Artery Bypass*
Humans
Immunoassay
Ischemia / metabolism
Ischemia / physiopathology
Male
NAD / metabolism
Nerve Growth Factors / metabolism
Neurons / enzymology*
Neurons / pathology
Postoperative Period
Rats
S100 Calcium Binding Protein beta Subunit
S100 Proteins / metabolism

Substances

Nerve Growth Factors
S100 Calcium Binding Protein beta Subunit
S100 Proteins
NAD
ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1