Abstract
Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay.
Publication types
-
Clinical Trial
-
Comparative Study
-
Controlled Clinical Trial
-
Randomized Controlled Trial
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Administration, Topical
-
Adult
-
Anti-Inflammatory Agents / administration & dosage
-
Anti-Inflammatory Agents / pharmacokinetics*
-
Betamethasone / administration & dosage
-
Betamethasone / analogs & derivatives*
-
Betamethasone / pharmacokinetics*
-
Double-Blind Method
-
Fluocinolone Acetonide / administration & dosage
-
Fluocinolone Acetonide / pharmacokinetics*
-
Glucocorticoids
-
Humans
-
Middle Aged
-
Therapeutic Equivalency
-
Vasoconstriction
Substances
-
Anti-Inflammatory Agents
-
Glucocorticoids
-
Fluocinolone Acetonide
-
betamethasone-17,21-dipropionate
-
Betamethasone