Abstract
The effects of gamma-irradiation on inflammatory gene expression, including NF-kappaB activation, in the kidney of C57/BL6 mice exposed to 1-9 Gy doses of (60)Co gamma-irradiation. Radiation enhanced the NF-kappaB activation and oxidative stress caused a dose-dependent disruption in the redox balance. The significance of this study is the new molecular information gained on gamma-irradiation effects through the activation of pro-inflammatory genes by NF-kappaB via the MAPK signaling pathway. Considering the exquisite sensitivity of NF-kappaB and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cobalt Radioisotopes
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Enzyme Activation / radiation effects
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Gamma Rays*
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Glutathione Disulfide / metabolism
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Inflammation Mediators / metabolism*
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Kidney / metabolism
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Kidney / radiation effects
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Lipid Peroxidation / radiation effects
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Mice
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Mice, Inbred C57BL
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Mitogen-Activated Protein Kinases / metabolism
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NF-kappa B / metabolism*
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Oxidation-Reduction / radiation effects
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Reactive Oxygen Species / metabolism
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Signal Transduction / radiation effects*
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Up-Regulation / radiation effects
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Whole-Body Irradiation / methods*
Substances
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Cobalt Radioisotopes
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Inflammation Mediators
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NF-kappa B
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Reactive Oxygen Species
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Mitogen-Activated Protein Kinases
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Glutathione Disulfide