Abstract
DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Viral / genetics
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Antigens, Viral / immunology*
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Disease Models, Animal
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Encephalitis Virus, Western Equine / genetics
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Encephalitis Virus, Western Equine / immunology*
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Encephalomyelitis, Equine / prevention & control*
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Female
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Mice
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Mice, Inbred BALB C
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Survival Analysis
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Vaccines, DNA / immunology*
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Viral Structural Proteins / genetics
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Viral Structural Proteins / immunology*
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Viral Vaccines / immunology*
Substances
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Antigens, Viral
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Vaccines, DNA
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Viral Structural Proteins
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Viral Vaccines