(11)C-PIB PET in subjective cognitive impairment

Eur Psychiatry. 2010 Mar;25(2):123-5. doi: 10.1016/j.eurpsy.2009.07.011. Epub 2009 Nov 18.

Abstract

People with Subjective Cognitive Impairment (SCI) may be at increased risk of dementia. In this study we examined amyloid load in 5 SCI subjects and 14 controls using PIB PET scanning. One SCI subject had significantly increased PIB retention in the cortical areas of interest. Larger, longitudinal studies are indicated.

MeSH terms

  • Aged
  • Amyloid / metabolism*
  • Biomarkers / metabolism
  • Carbon Radioisotopes
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / diagnostic imaging
  • Cognition Disorders / psychology
  • Cognition*
  • Dementia / diagnosis*
  • Dementia / diagnostic imaging
  • Dementia / psychology
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Memory*
  • Middle Aged
  • Neuropsychological Tests
  • Positron-Emission Tomography*
  • Risk Factors
  • United Kingdom

Substances

  • Amyloid
  • Biomarkers
  • Carbon Radioisotopes