A case of basophilic leukemia bearing simultaneous translocations t(8;21) and t(9;22)

Cancer Genet Cytogenet. 1991 Feb;51(2):215-21. doi: 10.1016/0165-4608(91)90134-g.

Abstract

We report a case of basophilic leukemia with simultaneous translocations of t(8;21) and t(9;22). The patient's clinical and hematologic findings were characteristic only of t(9;22) but not of t(8;21). This unusual cytogenetic phenomenon raises a challenge to the current concepts of primary chromosomal abnormalities in cancer.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 22*
  • Chromosomes, Human, Pair 8*
  • Chromosomes, Human, Pair 9*
  • Cyclophosphamide / therapeutic use
  • Cytarabine / therapeutic use
  • Drug Combinations
  • Humans
  • Karyotyping
  • Leukemia, Basophilic, Acute / diagnosis
  • Leukemia, Basophilic, Acute / drug therapy
  • Leukemia, Basophilic, Acute / genetics*
  • Male
  • Middle Aged
  • Philadelphia Chromosome
  • Prednisone / therapeutic use
  • Translocation, Genetic*
  • Vincristine / therapeutic use

Substances

  • Drug Combinations
  • Cytarabine
  • Vincristine
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • COAP protocol