Abstract
Methicillin-resistant Staphylococcus aureus isolates with vancomycin minimal inhibitory concentrations (MICs) >or=1.5 microg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MICs in 71 invasive pediatric community-acquired MRSA isolates from 2004 to 2008, using the E-test micromethod and the E-test macro-method. The modal MIC by micromethod was 1.5 microg/mL, and median vancomycin MICs did not increase over time.
Publication types
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Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Child
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Community-Acquired Infections / drug therapy*
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Community-Acquired Infections / microbiology
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Microbial Sensitivity Tests / methods
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Microbial Sensitivity Tests / standards*
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Vancomycin / pharmacology*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin