Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer

Anastasia Malek; Reinhold Schäfer; Oleg Tchernitsa

doi:10.1016/j.ctrv.2009.10.005

Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer

Cancer Treat Rev. 2010 Feb;36(1):8-15. doi: 10.1016/j.ctrv.2009.10.005. Epub 2009 Nov 28.

Authors

Anastasia Malek¹, Reinhold Schäfer, Oleg Tchernitsa

Affiliation

¹ Institute of Pathology, Charité Universitätsmedizin Berlin, Germany.

PMID: 19945796
DOI: 10.1016/j.ctrv.2009.10.005

Abstract

Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis / genetics
Cell Growth Processes / genetics
Female
Gene Expression Profiling
Gene Silencing*
Humans
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / pathology