[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis]

S Pineau; J-P Talarmin; F Morio; O Grossi; D Boutoille; F Léauté; P Le Pape; F Gay-Andrieu; M Miegeville; F Raffi

doi:10.1016/j.medmal.2009.10.005

[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis]

Med Mal Infect. 2010 Sep;40(9):541-3. doi: 10.1016/j.medmal.2009.10.005. Epub 2009 Nov 28.

[Article in French]

Authors

S Pineau¹, J-P Talarmin, F Morio, O Grossi, D Boutoille, F Léauté, P Le Pape, F Gay-Andrieu, M Miegeville, F Raffi

Affiliation

¹ Service des Maladies Infectieuses et Tropicales, CHU Hôtel-Dieu, 1 place Alexis-Ricordeau, 44093 Nantes cedex 1, France.

PMID: 19945807
DOI: 10.1016/j.medmal.2009.10.005

Abstract

We report a case of a pulmonary histoplasmosis in an HIV-positive patient usually living in Cambodia, with a positive Aspergillus galactomannan antigenemia resulting from a cross-reaction, that decreased after antifungal therapy. We discuss the potential interest of the detection of fungal DNA by PCR and Aspergillus galactomannan antigenemia for the diagnosis of histoplasmosis, especially in countries where Histoplasma capsulatum antigen testing is not available.

Publication types

Case Reports

MeSH terms

Antigens, Fungal / blood*
Aspergillus / immunology*
Galactose / analogs & derivatives
Histoplasmosis / blood*
Histoplasmosis / diagnosis*
Humans
Lung Diseases, Fungal / blood*
Lung Diseases, Fungal / diagnosis*
Male
Mannans / immunology*
Middle Aged
Molecular Biology

Substances

Antigens, Fungal
Mannans
galactomannan
Galactose