Abstract
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aza Compounds / chemical synthesis*
-
Aza Compounds / chemistry
-
Boron Compounds / chemistry*
-
Catalysis
-
Chloramines / chemistry*
-
Indoles / chemical synthesis*
-
Indoles / chemistry*
-
Magnetic Resonance Spectroscopy
-
Models, Chemical
-
Structure-Activity Relationship
-
Vinyl Compounds / chemistry*
Substances
-
Aza Compounds
-
Boron Compounds
-
Chloramines
-
Indoles
-
Vinyl Compounds
-
ethoxyvinylborolane