Abstract
The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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Biomimetic Materials / chemical synthesis*
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Biomimetic Materials / chemistry
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Chromatography, High Pressure Liquid
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Diaminopimelic Acid / analogs & derivatives*
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Diaminopimelic Acid / chemical synthesis*
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Diaminopimelic Acid / chemistry
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Metabolic Networks and Pathways
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Models, Molecular
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Spectrometry, Mass, Electrospray Ionization
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Succinates / chemical synthesis*
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Succinates / chemistry
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Succinyldiaminopimelate Transaminase / antagonists & inhibitors
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Succinyldiaminopimelate Transaminase / metabolism
Substances
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Succinates
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Diaminopimelic Acid
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Succinyldiaminopimelate Transaminase