Abstract
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzamides / chemical synthesis
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Benzamides / chemistry*
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Benzamides / pharmacology
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Drug Discovery
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Humans
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Parasitic Sensitivity Tests
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Trypanocidal Agents / chemical synthesis
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Trypanocidal Agents / chemistry*
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei brucei / drug effects
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Trypanosomiasis, African / drug therapy
Substances
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2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide
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Benzamides
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Trypanocidal Agents