An anatomical mouse model for multimodal molecular imaging

Xing Zhang; Jie Tian; Jinchao Feng; Shouping Zhu; Guorui Yan

doi:10.1109/IEMBS.2009.5335176

An anatomical mouse model for multimodal molecular imaging

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:5817-20. doi: 10.1109/IEMBS.2009.5335176.

Authors

Xing Zhang¹, Jie Tian, Jinchao Feng, Shouping Zhu, Guorui Yan

Affiliation

¹ Medical Image Processing Group, Institute of Automation, Chinese Academy of Sciences.

PMID: 19965250
DOI: 10.1109/IEMBS.2009.5335176

Abstract

In order to evaluate and improve multimodal molecular imaging technology, a three-dimensional anatomical model of a BALB/c mouse was developed based on micro-CT imaging with a liver-specific contrast agent Fenestra LC. By using image processing and interactive segmentation methods, we delineated some primary organs and tissues, including the skin, skeleton, muscle, heart, lung, liver and spleen. Finally, cone-beam x-ray CT and bioluminescence tomography simulation experiments demonstrate the availability and flexibility of the proposed mouse model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Equipment Design
Equipment Failure Analysis
Luminescent Measurements / instrumentation*
Mice / anatomy & histology*
Models, Anatomic*
Molecular Probe Techniques / instrumentation*
Phantoms, Imaging*
Whole Body Imaging / instrumentation*
Whole Body Imaging / methods