Isolated pelvic organ prolapse or together with urinary or fecal incontinence are frequently associated with peripheral neuropathy. This peripheral neuropathy could be seen as the cause or sometimes the consequence of the prolapse itself. Most of the studies have looked at the relationships between neuropathy and fecal incontinence. However, concerning urogenital prolapses, it seems that any peripheral denervation would lead to an exacerbation of the prolapse due to the weakness of the pelvic floor. Electromyography and electrophysiological tests are the only options to demonstrate objectively the peripheral neuropathy associated with pelvic organ prolapse. Those tests should not be performed systematically but only if there is any clinical suspicion of an underlying neuropathy.