Abstract
The incidence of myositis has been increasing since the advent of the epidemic of community-associated methicillin-resistant Staphylococcus aureus infection, and Panton-Valentine leukocidin has been implicated as a factor contributing to more-severe muscle injury. We report a case of severe myositis accompanying septic osteomyelitis and necrotizing fasciitis caused by a Panton-Valentine leukocidin-positive S. aureus strain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Bacterial Toxins / metabolism*
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Child
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Exotoxins / metabolism*
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Fasciitis, Necrotizing / drug therapy
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Fasciitis, Necrotizing / microbiology*
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Histocytochemistry
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Humans
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Leukocidins / metabolism*
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Male
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Myositis / drug therapy
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Myositis / microbiology*
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Polymerase Chain Reaction
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Radiography
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Shoulder / diagnostic imaging
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Shoulder / microbiology
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Staphylococcus aureus / genetics
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Staphylococcus aureus / metabolism
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Staphylococcus aureus / pathogenicity*
Substances
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin