The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187

Haematologica. 2009 Dec;94(12):1783-4. doi: 10.3324/haematol.2009.012708.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects
  • Blood Platelets / cytology
  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Calcimycin / pharmacology*
  • Caspase 3 / metabolism*
  • Coagulants / pharmacology
  • Enzyme Activation / drug effects
  • Eptifibatide
  • Flow Cytometry
  • Humans
  • Ionophores / pharmacology
  • Peptides / pharmacology
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Thrombin / pharmacology*
  • Tirofiban
  • Tyrosine / analogs & derivatives
  • Tyrosine / pharmacology

Substances

  • Coagulants
  • Ionophores
  • Peptides
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Calcimycin
  • Tyrosine
  • Thrombin
  • Caspase 3
  • Tirofiban
  • Eptifibatide