Heart transplantation in a low-organ-donation environment: a single center experience

Transplant Proc. 2009 Dec;41(10):4289-93. doi: 10.1016/j.transproceed.2009.09.079.

Abstract

Objective: Heart transplantation is the "gold standard" for treating patients in end-stage heart failure who satisfy strict selection criteria. However, infrequent transplant performance, eg, less than nine per year, may be associated with suboptimal results.

Methods: We reviewed our 13-year clinical experience (1996-2008) with 73 orthotopic heart transplants performed under strict selection criteria and followed closely thereafter at the only accredited center in Greece, a country with an annual rate of only seven donors per million population.

Results: Low perioperative (5.47%) and long-term (7.5%) mortality rates were responsible for a 94% survival rate in the first year, 92% at five years, and 70% at ten years-similar to those reported worldwide-along with excellent functional recovery.

Conclusion: Strict recipient and donor selection criteria, combined with a rigorous multidisciplinary follow-up, yield excellent results despite the existing shortage of available grafts.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cadaver
  • Female
  • Greece
  • Heart Diseases / classification
  • Heart Diseases / surgery
  • Heart Failure / surgery
  • Heart Transplantation / mortality
  • Heart Transplantation / statistics & numerical data*
  • Humans
  • Male
  • Middle Aged
  • Patient Selection
  • Postoperative Care
  • Preoperative Care
  • Retrospective Studies
  • Safety
  • Survival Rate
  • Survivors
  • Tissue Donors / statistics & numerical data*
  • Young Adult