Abstract
An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based on their spectral analysis. Compounds 2, 3, 4 and 5 showed significant anti-influenza viruses activities. Compared with ribavirin, EFMS appeared to have similar efficacy against influenza viruses, was considered to be less toxic and may warrant further evaluation as a possible agent for the treatment of influenza.
Copyright 2009 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use*
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Apigenin / isolation & purification
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Apigenin / pharmacology
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Apigenin / therapeutic use
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Dogs
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Flavones / isolation & purification
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Flavones / pharmacology
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Flavones / therapeutic use*
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Influenza A virus / drug effects*
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Lamiaceae / chemistry*
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Male
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Mice
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Mice, Inbred ICR
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Orthomyxoviridae Infections / drug therapy*
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Orthomyxoviridae Infections / virology
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Ribavirin
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Triterpenes / isolation & purification
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Ursolic Acid
Substances
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Antiviral Agents
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Flavones
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Plant Extracts
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Triterpenes
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Ribavirin
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Apigenin
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acacetin