N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide. A novel, systemically active antitumor agent effective against 3LL Lewis lung carcinoma

J Med Chem. 1991 Mar;34(3):914-8. doi: 10.1021/jm00107a007.

Abstract

N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxam ide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing established micrometastatic 3LL Lewis lung carcinoma. Amide 1 is effective after either oral or intraperitoneal dosing in acute, subacute, or chronic regimens. 1 is well tolerated in this model with an excellent therapeutic index relative to the cytotoxic anticancer drug adriamycin.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Chemical Phenomena
  • Chemistry
  • Doxorubicin / therapeutic use
  • Guanidines / administration & dosage
  • Guanidines / chemistry
  • Guanidines / therapeutic use*
  • Lung Neoplasms / drug therapy*
  • Mice
  • Molecular Structure
  • Thiazoles / administration & dosage
  • Thiazoles / chemistry
  • Thiazoles / therapeutic use*

Substances

  • Antineoplastic Agents
  • Guanidines
  • Thiazoles
  • N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide
  • Doxorubicin