Sequence types and antimicrobial susceptibility of invasive streptococcus pneumoniae isolates from a region with high antibiotic selective pressure and suboptimal vaccine coverage

Pediatr Infect Dis J. 2010 May;29(5):467-9. doi: 10.1097/INF.0b013e3181cb45f3.

Abstract

Multilocus sequence typing was carried out on 95 invasive pneumococcal isolates belonging to the most common 7 serotypes currently circulating in Taiwan. The study confirmed continued prevalence in Taiwan of a few global clones and sequence types (STs) since the mid-1990s and identified the recent emergence of ST320 (19A) and ST902 (6A). Antimicrobial nonsusceptibility was common in the predominant STs of serotypes 14, 19A, 19F, and 23F.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Typing Techniques*
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Genotype
  • Humans
  • Infant
  • Microbial Sensitivity Tests
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / microbiology*
  • Pneumococcal Vaccines / immunology
  • Selection, Genetic
  • Sequence Analysis, DNA
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / isolation & purification
  • Taiwan / epidemiology
  • Vaccination / statistics & numerical data

Substances

  • Anti-Bacterial Agents
  • Pneumococcal Vaccines