An accelerated failure time mixture cure model with masked event

Biom J. 2009 Dec;51(6):932-45. doi: 10.1002/bimj.200800244.

Abstract

We extend the Dahlberg and Wang (Biometrics 2007, 63, 1237-1244) proportional hazards (PH) cure model for the analysis of time-to-event data that is subject to a cure rate with masked event to a setting where the PH assumption does not hold. Assuming an accelerated failure time (AFT) model with unspecified error distribution for the time to the event of interest, we propose rank-based estimating equations for the model parameters and use a generalization of the EM algorithm for parameter estimation. Applying our proposed AFT model to the same motivating breast cancer dataset as Dahlberg and Wang (Biometrics 2007, 63, 1237-1244), our results are more intuitive for the treatment arm in which the PH assumption may be violated. We also conduct a simulation study to evaluate the performance of the proposed method.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Causality
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Endpoint Determination / methods*
  • Female
  • Humans
  • Models, Statistical*
  • Outcome Assessment, Health Care / methods*
  • Proportional Hazards Models*
  • Risk Assessment / methods
  • Risk Factors
  • Sensitivity and Specificity
  • Time Factors
  • Treatment Failure*
  • Treatment Outcome