Abstract
Knowledge of what determines the developmental competence of oocytes during folliculogenesis is poor. This review, through the analysis of the expression profile of developmentally competent or incompetent mouse oocytes, summarizes the results of recent studies showing that the Oct-4 transcription factor regulating the expression of Stella and Foxj2 at the Nanog locus could play a pivotal role in the establishment of the oocyte's developmental competence.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chromosomal Proteins, Non-Histone
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Female
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / metabolism
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Gene Expression Regulation, Developmental
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Mice
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Octamer Transcription Factor-3 / physiology*
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Oocytes / growth & development*
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Oocytes / metabolism
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Proteins / genetics
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Proteins / metabolism
Substances
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Chromosomal Proteins, Non-Histone
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DPPA3 protein, human
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FOXJ2 protein, human
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Forkhead Transcription Factors
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Octamer Transcription Factor-3
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Proteins