We have experienced a case of successful control of recurrent duodenal carcinoma receiving paclitaxel chemotherapy. A 61-year-old woman with epigastralgia was diagnosed with pyloric gastric carcinoma upon upper gastrointestinal endoscopy and biopsy. Distal gastrectomy with D2 dissection was performed. However, at the resected organ, the lesion was on the duodenum. So, we additionally resected the anal edge. And 13a, 13b, 12a, p lymph nodes were dissected for duodenal carcinoma. Later, the CEA level was increased, and abdominal CT scan showed swelling of paraaortic lymph nodes. Recurrence of the duodenal carcinoma was diagnosed in February 2007, and S-1 administration was begun. But, we dosed down with S-1 due to severe diarrhea. In spite of combined S-1 and CPT-11 chemotherapy, the CEA level increased, and lymph nodes were getting larger. She then underwent the paclitaxel chemotherapy during the 5 months without severe side effects. The CEA level decreased significantly and metastatic lymph nodes were reduced observed by CT scan. Paclitaxel chemotherapy is effective for duodenal cancer.