Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives

Deepak Kumar; Seema Joshi; Rajesh K Rohilla; Nilanjan Roy; Diwan S Rawat

doi:10.1016/j.bmcl.2009.12.074

Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives

Bioorg Med Chem Lett. 2010 Feb 1;20(3):893-5. doi: 10.1016/j.bmcl.2009.12.074. Epub 2009 Dec 24.

Authors

Deepak Kumar¹, Seema Joshi, Rajesh K Rohilla, Nilanjan Roy, Diwan S Rawat

Affiliation

¹ Department of Chemistry, University of Delhi, Delhi 110 007, India.

PMID: 20047831
DOI: 10.1016/j.bmcl.2009.12.074

Abstract

A series of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives with different substitution pattern on the aromatic ring have been prepared and evaluated for their antibacterial activity against Gram-positive and Gram-negative bacterial strains. Most of the compounds exhibit potent activity against Pseudomonas aeruginosa and Staphylococcus epidermidis while compounds 6l and 6m showed antibacterial activity against all the four bacterial strains with MIC values ranging from 0.002 to 0.016 microg/mL and no hemolytic activity up to 512 microg/mL in mammalian erythrocytes was observed.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Benzylamines / chemical synthesis
Benzylamines / pharmacology
Cyclohexanes / chemical synthesis
Cyclohexanes / pharmacology
Drug Resistance, Multiple, Bacterial / drug effects
Drug Resistance, Multiple, Bacterial / physiology*
Gram-Negative Bacteria / drug effects
Gram-Negative Bacteria / growth & development
Gram-Positive Bacteria / drug effects
Gram-Positive Bacteria / growth & development
Humans
Microbial Sensitivity Tests / methods

Substances

Anti-Bacterial Agents
Benzylamines
Cyclohexanes