Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

O Rosnet; M G Matteï; S Marchetto; D Birnbaum

doi:10.1016/0888-7543(91)90270-o

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

Genomics. 1991 Feb;9(2):380-5. doi: 10.1016/0888-7543(91)90270-o.

Authors

O Rosnet¹, M G Matteï, S Marchetto, D Birnbaum

Affiliation

¹ U.119 INSERM, Marseille, France.

PMID: 2004790
DOI: 10.1016/0888-7543(91)90270-o

Abstract

We have isolated and sequenced part of a new gene of the tyrosine kinase family. This gene, called FLT3, has strong sequence similarities with members of a group of genes encoding growth factor receptors: FMS, KIT, and PDGFR. We have localized the human FLT3 gene to chromosome 13, band q12, and its mouse homolog to chromosome 5, region G.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 13*
ErbB Receptors / genetics
Genes, fms
Humans
Male
Mice
Molecular Sequence Data
Multigene Family
Protein-Tyrosine Kinases / genetics*
Protein-Tyrosine Kinases / metabolism
Sequence Homology, Nucleic Acid
Testis / enzymology

Substances

ErbB Receptors
Protein-Tyrosine Kinases