Abstract
Phenotypic and genotypic methods were used to characterize extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli isolated in 2007 from 11 different Canadian medical centers. Of the 209 ESBL-producing E. coli isolates tested, 148 (71%) produced CTX-M-15, 17 (8%) produced CTX-M-14, 5 (2%) produced CTX-M-3, and 1 produced CTX-M-27. Overall, 96 (46%) of the ESBL producers belonged to clonal complex ST131, with the highest prevalence in Brampton, Calgary, and Winnipeg. ST131 is an important cause of community onset urinary tract infections due to ESBL-producing E. coli across Canada.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Typing Techniques
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Canada / epidemiology
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology
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Escherichia coli / classification
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Escherichia coli / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / epidemiology*
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Humans
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Microbial Sensitivity Tests
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Prevalence
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Urinary Tract Infections / epidemiology*
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Urinary Tract Infections / microbiology
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Escherichia coli Proteins
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beta-lactamase CTX-M-14
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beta-lactamase CTX-M-15
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beta-Lactamases