[Role of pendoxifiline (PTX) in different and cute and chronic models of pain in rats]

Łukasz Nowak; Daniel Zurowski; Jarosław Garlicki; Piotr J Thor

[Role of pendoxifiline (PTX) in different and cute and chronic models of pain in rats]

Folia Med Cracov. 2008;49(3-4):103-9.

[Article in Polish]

Authors

Łukasz Nowak¹, Daniel Zurowski, Jarosław Garlicki, Piotr J Thor

Affiliation

¹ Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. [email protected]

PMID: 20050583

Abstract

Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production. The aim of this study was to evaluate behavioural activity changes in response to acute and chronic nociceptive stimulus. PTX was more effective in neuropathic pain than acute pain model. Use of cytokine inhibitors might offer new strategies of drug-resistant chronic pain treatment.

Publication types

English Abstract

MeSH terms

Acute Disease
Animals
Chronic Disease
Cytokines / drug effects
Dose-Response Relationship, Drug
Inflammation / drug therapy*
Male
Nervous System Diseases / drug therapy*
Nervous System Diseases / surgery
Nociceptors / drug effects
Nociceptors / metabolism
Pain Measurement
Pain Threshold / drug effects
Pain Threshold / physiology*
Pentoxifylline / administration & dosage*
Pentoxifylline / metabolism*
Premedication*
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha / drug effects

Substances

Cytokines
Tumor Necrosis Factor-alpha
Pentoxifylline