Takayasu's arteritis (TA) is a rare vascular disorder, which predominantlly affects aorta and its primary branches. TA has a worldwide distribution and it is most frequent in young women. We report the case report of 36-year-old women, who underwent replacement of aortic valve and ascending aorta due to signifiant aortic regurgitation and dilatation of ascending aorta as a consequence of TA.