Experimental approaches to the study of epigenomic dysregulation in ageing

Reid F Thompson; Melissa J Fazzari; John M Greally

doi:10.1016/j.exger.2009.12.013

Experimental approaches to the study of epigenomic dysregulation in ageing

Exp Gerontol. 2010 Apr;45(4):255-68. doi: 10.1016/j.exger.2009.12.013. Epub 2010 Jan 10.

Authors

Reid F Thompson¹, Melissa J Fazzari, John M Greally

Affiliation

¹ Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

Publication types

Review

MeSH terms

Aging / genetics*
Aging / physiology
Amino Acid Sequence
Animals
DNA Methylation / genetics
DNA Methylation / physiology
Epigenesis, Genetic / genetics*
Epigenesis, Genetic / physiology
Histones / genetics
Histones / physiology
Humans
Molecular Sequence Data
Mutation / genetics*

Substances

Histones

Abstract

Publication types

MeSH terms

Substances

Grants and funding