Targeting multiple biofilm pathways

Erik C Hett; Deborah T Hung

doi:10.1016/j.chembiol.2009.12.003

Targeting multiple biofilm pathways

Chem Biol. 2009 Dec 24;16(12):1216-8. doi: 10.1016/j.chembiol.2009.12.003.

Authors

Erik C Hett¹, Deborah T Hung

Affiliation

¹ Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

PMID: 20064430
DOI: 10.1016/j.chembiol.2009.12.003

Abstract

Cegelski et al. (2009) demonstrate the importance of amyloid production for biofilm formation and host colonization using several mutant strains of pathogenic E. coli and small molecule inhibitors. This work reveals a path forward for studying the role of bacterial amyloids in vivo and suggests the potential for small molecules to target multiple biofilm formation pathways.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Bacterial Adhesion
Bacterial Proteins / antagonists & inhibitors
Bacterial Proteins / metabolism
Biofilms / drug effects
Biofilms / growth & development*
Disease Models, Animal
Fimbriae, Bacterial / chemistry
Fimbriae, Bacterial / metabolism
Mice
Quorum Sensing
Uropathogenic Escherichia coli / metabolism

Substances

Anti-Bacterial Agents
Bacterial Proteins
Crl protein, Bacteria