Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

Christian R Kowol; Robert Trondl; Vladimir B Arion; Michael A Jakupec; Irene Lichtscheidl; Bernhard K Keppler

doi:10.1039/b919119b

Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

Dalton Trans. 2010 Jan 21;39(3):704-6. doi: 10.1039/b919119b. Epub 2009 Oct 22.

Authors

Christian R Kowol¹, Robert Trondl, Vladimir B Arion, Michael A Jakupec, Irene Lichtscheidl, Bernhard K Keppler

Affiliation

¹ University of Vienna, Institute of Inorganic Chemistry, Währingerstr. 42, A-1090, Vienna, Austria.

PMID: 20066211
DOI: 10.1039/b919119b

Abstract

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / metabolism*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Fluorescence*
Humans
Microscopy, Fluorescence
Organometallic Compounds / chemistry*
Organometallic Compounds / metabolism*
Organometallic Compounds / pharmacology
Pyridines / chemistry*
Thiosemicarbazones / chemistry*
Zinc / chemistry*

Substances

Antineoplastic Agents
Organometallic Compounds
Pyridines
Thiosemicarbazones
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
Zinc