Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity

Biochem Pharmacol. 1991 Apr 15;41(8):1255-9. doi: 10.1016/0006-2952(91)90666-s.

Abstract

The data reported suggest that--following initiation of lipid peroxidation--membrane protein thiols can be attacked by lipid-derived radicals and/or reactive, lipid-soluble aldehydes like 4-hydroxynonenal and other hydroxyalkenals originated within the lipid core of cell membranes, resulting in a membrane protein thiol loss which is in turn associated with the development of hepatocellular injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Propanol / toxicity
  • Acrolein / toxicity
  • Animals
  • Glutathione / metabolism
  • Lipid Peroxides / metabolism*
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Membrane Proteins / metabolism*
  • Mice
  • Microsomes, Liver / drug effects
  • Mitochondria, Liver / drug effects
  • Propanols*
  • Sulfhydryl Compounds / metabolism*

Substances

  • Lipid Peroxides
  • Membrane Proteins
  • Propanols
  • Sulfhydryl Compounds
  • allyl alcohol
  • Acrolein
  • 1-Propanol
  • Glutathione