Abstract
Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Acyl-Butyrolactones / metabolism
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / metabolism
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification*
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Benzopyrans / metabolism
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Burkholderia / chemistry
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Burkholderia / metabolism*
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Gene Expression Regulation, Bacterial
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Humans
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Quorum Sensing*
Substances
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Acyl-Butyrolactones
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Anti-Bacterial Agents
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Benzopyrans
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bactobolin D
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bactobolin